QUICK ANSWERStart with the tool that matches your immediate input.
Open Grayscale PDF first when its stated purpose matches the result you need now. Use Highlight PDF Areas only when it solves a separate next task.
This guide is for students, office teams, administrators, and document-heavy workflows. Start with Grayscale PDF when your immediate task is to use the Grayscale PDF to complete this file task privately in your browser. Move to Highlight PDF Areas only when you also need to use the Highlight PDF Areas to complete this file task privately in your browser.
The goal is not to run two tools automatically. It is to finish the first narrow task, inspect its result, and then decide whether Highlight PDF Areas solves a genuinely different next step.
Both tools sit in PDF Tools, but they handle different inputs or outcomes. Keeping those roles separate reduces repeated work and makes verification easier.